Onset of dyskinesia with adjunct ropinirole prolonged‐release or additional levodopa in early Parkinson's disease
Identifieur interne : 001B38 ( Main/Exploration ); précédent : 001B37; suivant : 001B39Onset of dyskinesia with adjunct ropinirole prolonged‐release or additional levodopa in early Parkinson's disease
Auteurs : Ray L. Watts [États-Unis] ; Kelly E. Lyons [États-Unis] ; Rajesh Pahwa [États-Unis] ; Kapil Sethi [États-Unis] ; Matthew Stern [États-Unis] ; Robert A. Hauser [États-Unis] ; Warren Olanow [États-Unis] ; Alex M. Gray [États-Unis] ; Bryan Adams [États-Unis] ; Nancy L. Earl [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Antiparkinson Agents (adverse effects), Delayed-Action Preparations (adverse effects), Disability Evaluation, Drug Administration Schedule, Drug Therapy, Combination, Dyskinesia, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (epidemiology), Dyskinesia, Drug-Induced (etiology), Female, Humans, Indoles (adverse effects), Levodopa, Levodopa (adverse effects), Male, Middle Aged, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Parkinson disease, Parkinson's disease, Quality of Life (psychology), Questionnaires, Release, Ropinirole, dyskinesia, levodopa, ropinirole prolonged‐release.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Delayed-Action Preparations, Indoles, Levodopa.
- diagnosis : Dyskinesia, Drug-Induced.
- drug therapy : Parkinson Disease.
- epidemiology : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- psychology : Quality of Life.
- Adult, Age of Onset, Aged, Disability Evaluation, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Questionnaires.
Abstract
Levodopa‐induced dyskinesia can result in significant functional disability and reduced quality of life in patients with Parkinson's disease (PD). The goal of this study was to determine if the addition of once‐daily ropinirole 24‐hour prolonged‐release (n = 104) in PD patients not optimally controlled with levodopa after up to 3 years of therapy with less than 600 mg/d delays the onset of dyskinesia compared with increasing doses of levodopa (n = 104). During the study, 3% of the ropinirole prolonged‐release group (mean dose 10 mg/d) and 17% of the levodopa group (mean additional dose 284 mg/d) developed dyskinesia (P < 0.001). There were no significant differences in change in Unified Parkinson's Disease Rating Scale activities of daily living or motor scores, suggesting comparable efficacy between the two treatments. Adverse events were comparable in the two groups with nausea, dizziness, insomnia, back pain, arthralgia, somnolence, fatigue, and pain most commonly reported. Ropinirole prolonged‐release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22890
Affiliations:
- États-Unis
- Alabama, Caroline du Nord, Floride, Géorgie (États-Unis), Kansas, Pennsylvanie, État de New York
- Tampa
- Université de Floride du Sud
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Le document en format XML
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<term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Delayed-Action Preparations (adverse effects)</term>
<term>Disability Evaluation</term>
<term>Drug Administration Schedule</term>
<term>Drug Therapy, Combination</term>
<term>Dyskinesia</term>
<term>Dyskinesia, Drug-Induced (diagnosis)</term>
<term>Dyskinesia, Drug-Induced (epidemiology)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Indoles (adverse effects)</term>
<term>Levodopa</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Quality of Life (psychology)</term>
<term>Questionnaires</term>
<term>Release</term>
<term>Ropinirole</term>
<term>dyskinesia</term>
<term>levodopa</term>
<term>ropinirole prolonged‐release</term>
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<term>Delayed-Action Preparations</term>
<term>Indoles</term>
<term>Levodopa</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Quality of Life</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Questionnaires</term>
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<term>Libération</term>
<term>Lévodopa</term>
<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Levodopa‐induced dyskinesia can result in significant functional disability and reduced quality of life in patients with Parkinson's disease (PD). The goal of this study was to determine if the addition of once‐daily ropinirole 24‐hour prolonged‐release (n = 104) in PD patients not optimally controlled with levodopa after up to 3 years of therapy with less than 600 mg/d delays the onset of dyskinesia compared with increasing doses of levodopa (n = 104). During the study, 3% of the ropinirole prolonged‐release group (mean dose 10 mg/d) and 17% of the levodopa group (mean additional dose 284 mg/d) developed dyskinesia (P < 0.001). There were no significant differences in change in Unified Parkinson's Disease Rating Scale activities of daily living or motor scores, suggesting comparable efficacy between the two treatments. Adverse events were comparable in the two groups with nausea, dizziness, insomnia, back pain, arthralgia, somnolence, fatigue, and pain most commonly reported. Ropinirole prolonged‐release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa. © 2010 Movement Disorder Society</div>
</front>
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<tree><country name="États-Unis"><region name="Alabama"><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
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<name sortKey="Adams, Bryan" sort="Adams, Bryan" uniqKey="Adams B" first="Bryan" last="Adams">Bryan Adams</name>
<name sortKey="Earl, Nancy L" sort="Earl, Nancy L" uniqKey="Earl N" first="Nancy L." last="Earl">Nancy L. Earl</name>
<name sortKey="Gray, Alex M" sort="Gray, Alex M" uniqKey="Gray A" first="Alex M." last="Gray">Alex M. Gray</name>
<name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name>
<name sortKey="Olanow, Warren" sort="Olanow, Warren" uniqKey="Olanow W" first="Warren" last="Olanow">Warren Olanow</name>
<name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name>
<name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name>
<name sortKey="Stern, Matthew" sort="Stern, Matthew" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name>
</country>
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